Development and evaluation of organic silicon nanoparticles/ Desenvolvimento e avaliação de nanopartículas de silício orgânico

Rosana Letícia da Rosa, Luana Serbai, Robson Schimandeiro Novak, Josiane de Fátima Padilha de Paula, Ana Cristina Oltramari Toledo, Vanessa Von Mühlen de Carvalho, Patricia Mathias Döll Boscardin

Abstract


Skin is an important component of outer beauty, it is the focus of many surgical and non-surgical procedures. Skin changes associated with intrinsic or extrinsic aging, such as wrinkles, sagging and pigmentation changes, can cause people to look for cosmetic procedures to improve the appearance of their skin. Studies demonstrate the importance of organic silicon in the production of type I collagen. The present work aimed to study the development of Silicium P® polymer nanoparticles. The suspension of nanoparticles was obtained by the technique of double emulsification-evaporation of the solvent where the physicochemical characterization was performed. These presented mean diameter of 562 nm, zeta potential of -37.2 mV and polydispersity index of 0.42. It was also obtained the infrared spectrum with Fourier transform where it showed that there were no molecular interactions that alter the chemical structures of the components of the formulation during the process of obtaining the nanoparticles.

 


Keywords


Collagen; Silicium P®; Skin aging; Nanoparticle.

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References


VERHAEGEN, Pauline D. et al. Adaptation of the dermal collagen structure of human skin and scar tissue in response to stretch: an experimental study. Wound Repair and Regeneration, v. 20, n. 5, p. 658-666, 2012.

ZOUBOULIS, Christos C.; MAKRANTONAKI, Evgenia. Clinical aspects and molecular diagnostics of skin aging. Clinics in dermatology, v. 29, n. 1, p. 3-14, 2011.

LI, Zhaoping et al. Absorption of silicon from artesian aquifer water and its impact on bone health in postmenopausal women: a 12 week pilot study. Nutrition journal, v. 9, n. 1, p. 44, 2010.

REFFITT, D. M. et al. Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro. Bone, v. 32, n. 2, p. 127-135, 2003.

UITTO, Jouni; BERNSTEIN, Eric F. Molecular mechanisms of cutaneous aging: connective tissue alterations in the dermis. In: Journal of Investigative Dermatology Symposium Proceedings. Elsevier, 1998. p. 41-44.

SCHAFFAZICK, Scheila Rezende et al. Caracterização e estabilidade físico-química de sistemas poliméricos nanoparticulados para administração de fármacos. Química nova. São Paulo. Vol. 26, n. 5 (2003), p. 726-737, 2003.

SOUTO, B. E.; SEVERINO, P.; SANTANA, H. M. Preparação de Nanopartículas Poliméricas a partir de Polímeros Pré-formados – Parte II. Polímeros, vol. 22, n. 1, p. 101-106, 2012.

SOARES, Margarida et al. Permeação cutânea: desafios e oportunidades. Journal of Basic and Applied Pharmaceutical Sciencies, v. 36, n. 3, 2016.

VERMA, D. D., VERMA, S., BLUME, G., et al. Particle size of liposomes influences dermal delivery of substances into skin. International journal of pharmaceutics, v. 258, n. 1-2, p. 141-151, 2003.

AVADI, M. R. et al. Preparation and characterization of insulin nanoparticles using chitosan and Arabic gum with ionic gelation method. Nanomedicine: Nanotechnology, Biology, and Medicine, v. 6, p. 58–63, 2010.

MOSQUEIRA, Vanessa Carla Furtado et al. Poly (D, L‐lactide) nanocapsules prepared by a solvent displacement process: Influence of the composition on physicochemical and structural properties. Journal of pharmaceutical sciences, v. 89, n. 5, p. 614-626, 2000.

NEVES, A. R. et al. Novel resveratrol nanodelivery systems based on lipid nanoparticles to enhance its oral bioavailability. Int Journal of Nanomedicine, v. 8, p.177-187, 2013.

MORA-HUERTAS, C. E.; FESSI, H.; ELAISSARI, A. Polymer-based nanocapsules for drug delivery. International journal of pharmaceutics, v. 385, n. 1-2, p. 113-142, 2010.

PAVIA, D. L., LAMPMAN, M. G., KRIZ, S. G., et al. Introdução à Espectroscopia. 4ª ed. Cengage Learning, São Paulo, 2010.




DOI: https://doi.org/10.34117/bjdv6n3-255

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