Is there a relationship between hippocampus-dependent memory and 5-ht2a receptors? Insights from a systematic review / Há uma relação entre a memória hipocampo-dependente e receptores 5-HT2a? Insights de uma revisão sistemática

Rafael Danyllo da Silva Miguel, José Elias Bezerra Barros, Gilmar Franca Nobre Junior, Isabella Cristinna da Silva Costa, José Emerson Xavier, Lisiane dos Santos Oliveira, Bruna Del Vechio Koike, Sandra Lopes de Souza

Abstract


This is a systematic review with the aim of analyzing the role of 5-HT2A receptors in hippocampal-dependent memory. In order to do this, we searched the PubMed, Science Direct, and Neuron databases between October 23 and 29, 2018, using the following descriptor combinations: memory, 5-HT2A, and hippocampus, present in the title, abstract, or keywords, with no restrictions on study date or language. Following search and selection, we analyzed risk of bias, and the results were subsequently synthesized according to the experimental model. Out of 40 articles, four were included in qualitative analysis. The data indicate that the 5-HT2A receptors in the hippocampus play an important role in the memory consolidation process, although they do not interfere in the encoding or retrieval processes of these memories. Additionally, chronic use of receptor agonists in models of Alzheimer’s disease also demonstrates better performance in the object recognition tests. The action of 5-HT2A receptors has also been shown to be important to aversive memory formation, thus attributing a prominent role to these receptors in hippocampal-dependent memory processes.


Keywords


Memory, Hippocampus, Serotonin, 5-HT2A receptor

Full Text:

PDF

References


Afshar, Simin et al. 2018. “The Effect of NAD-299 and TCB-2 on Learning and Memory , Hippocampal BDNF Levels and Amyloid Plaques in Streptozotocin-Induced Memory Deficits in Male Rats.” Psychopharmacology 235: 2809–22.

Bailey, Craig H et al. 2000. “Is heterosynaptic modulation essential for stabilizing hebbian plasticity and memory ?” 1(October): 1–10.

Bui, Anh D et al. 2018. “Dentate Gyrus Mossy Cells Control Spontaneous Convulsive Seizures and Spacial Memory.” Neuroscience 359(February): 787–90.

Cai, Xiang et al. 2013. “Local Potentiation of Excitatory Synapses by Serotonin and Its Alteration in Rodent Models of Depression.” Nature Publishing Group 16(4): 464–72. http://dx.doi.org/10.1038/nn.3355.

Cameron, HA, TG Hazel, and RD Mckay. 1998. “Regulation of Neurogenesis by Growth Factors and Neurotransmitters.” Journal of Neurobiology 36(2): 287–306.

Celada, Pau, M Victoria Puig, and Francesc Artigas. 2013. “Serotonin Modulation of Cortical Neurons and Networks.” 7(April): 1–20.

Cohen, Sarah J et al. 2013. “The Rodent Hippocampus Is Essential for Nonspatial Object Memory.” Current Biology 23(September): 1685–90.

Hagberg, Gul-Britt et al. 1998. “Stimulation of 5-HT 2A Receptors on Astrocytes in Primary Culture Opens Voltage-Independent Ca+2 Channels.” Neurochemistry international 32: 153–62.

Hammond, Rebecca S, Laura E Tull, and Robert W Stackman. 2004. “On the Delay-Dependent Involvement of the Hippocampus in Object Recognition Memory.” Neurobiology of Learning and Memory 82(April): 26–34.

Kandel, Eric R. 2009. “The Biology of Memory : A Forty-Year Perspective.” The journal of neuroscience 29(41): 12748–56.

Kandel, Eric R, Yadin Dudai, and Mark R Mayford. 2014. “Review The Molecular and Systems Biology of Memory.” Cell 157(1): 163–86. http://dx.doi.org/10.1016/j.cell.2014.03.001.

Kilkenny, Carol et al. 2009. “Survey of the Quality of Experimental Design , Statistical Analysis and Reporting of Research Using Animals.” Plos onde 4(11).

Meneses, Alfredo. 2007. “Stimulation of 5-HT1A, 5-HT1B, 5-HT2A/2C, 5-HT3 and 5-HT4 Receptors or 5-HT Uptake Inhibition: Short- and Long-Term Memory.” Behavioural Brain Research 184(june): 81–90.

Micheli, Laura, Manuela Ceccarelli, Giorgio D Andrea, and Felice Tirone. 2018. “Depression and Adult Neurogenesis : Positive Effects of the Antidepressant Fluoxetine and of Physical Exercise.” Brain Research Bulletin 143(September): 181–93. https://doi.org/10.1016/j.brainresbull.2018.09.002.

Mokler, David J et al. 1998. “Serotonin Neuronal Release From Dorsal Hippocampus Following Electrical Stimulation of the Dorsal and Median Raphe ´ Nuclei in Conscious Rats.” Hippocampus 273(8): 262–73.

Nasehi, Mohammad, Fatemeh Ghadimi, Fatemeh Khakpai, and Mohammad-reza Zarrindast. 2017. “Interaction between Harmane, a Class of β-Carboline Alkaloids, and the CA1 Serotonergic System in Modulation of Memory Acquisition.” Neuroscience Research. http://dx.doi.org/10.1016/j.neures.2017.03.011.

Nasehi, Mohammad, Mehdi Jamshidi-mehr, Fatemeh Khakpai, and Mohammad-reza Zarrindast. 2014. “Possible Involvement of CA1 5-HT1B/1D and 5-HT2A/2B/2C Receptors in Harmaline-Induced Amnesia.” Pharmacology, Biochemistry and Behavior (2013): 1–9. http://dx.doi.org/10.1016/j.pbb.2014.08.007.

Nichols, David E. 2012. “Structure – Activity Relationships of Serotonin 5-HT 2A Agonists.” Advanced Review 1(October): 559–79.

Novotná, R, and L Janský. 1976. “Effect of Different Environmental Temperatures on the Serotonin Concentration and Turnover in the Brain Stem of a Hibernator.” Physiol Bohemoslov. 25(1).

Palacios-filardo, Jon, and Jack R Mellor. 2019. “Neuromodulation of Hippocampal Long-Term Synaptic Plasticity.” Current Opinion in Neurobiology 54: 37–43. https://doi.org/10.1016/j.conb.2018.08.009.

Parrish, Jason C, Michael R Braden, Emily Gundy, and David E Nichols. 2005. “Differential Phospholipase C Activation by Phenylalkylamine Serotonin 5-HT 2A Receptor Agonists.” Journal of Neurochemistry 95(july): 1575–84.

Peddie, C J et al. 2008. “Colocalisation of Serotonin 2A Receptors with the Glutamate Receptor Subunits NR1 and GluR2 in the Dentate Gyrus : An Ultrastructural Study of a Modulatory Role ☆.” 211: 561–73.

Sigmund, Jessica C et al. 2008. “Fine-Mapping at the HTR2A Locus Reveals Multiple Episodic Memory-Related Variants.” Biological psychology 79: 239–42.

Teixeira, Catia M et al. 2018. “Hippocampal 5-HT Input Regulates Memory Formation and Schaffer Collateral Excitation.” Neuron 98(june): 1–13. https://doi.org/10.1016/j.neuron.2018.04.030.

Twarkowski, Hannah, Hardy Hagena, and Denise Manahan-vaughan. 2016. “The 5-Hydroxytryptamine 4 Receptor Enables Differentiation of Informational Content and Encoding in the Hippocampus.” 891(September 2015): 875–91.

Vaidya, Vidita A, Gerard J Marek, George K Aghajanian, and Ronald S Duman. 1997. “5-HT 2A Receptor-Mediated Regulation of Brain-Derived Neurotrophic Factor mRNA in the Hippocampus and the Neocortex.” 17(8): 2785–95.

Yohn, Christine N., Mark M. Gergues, and Benjamin Adam Samuels. 2017. “The Role of 5-HT Receptors in Depression Tim Bliss.” Molecular Brain 10(1): 1–12.

Yoshida, Hiroyuki et al. 2011. “Subtype Specific Roles of Serotonin Receptors in the Spine Formation of Cortical Neurons in Vitro.” Neuroscience Research 71(3): 311–14. http://dx.doi.org/10.1016/j.neures.2011.07.1824.

Zhang, Gongliang et al. 2013. “Stimulation of Serotonin 2A Receptors Facilitates Consolidation and Extinction of Fear Memory in C57BL / 6J Mice.” Neuropharmacology 64: 403–13. http://dx.doi.org/10.1016/j.neuropharm.2012.06.007.

Zhang, Gongliang, David Cinalli, Sarah J. Cohen, Kristina D. Knapp, Lisa M. Rios, José Martínez-Hernández, et al. 2016. “Examination of the Hippocampal Contribution to Serotonin 5-HT2Areceptor-Mediated Facilitation of Object Memory in C57BL/6J Mice.” Neuropharmacology 109: 332–40. http://dx.doi.org/10.1016/j.neuropharm.2016.04.033.

Zhang, Gongliang, David Cinalli, Sarah J Cohen, Kristina D Knapp, Lisa M Rios, and Robert W Stackman. 2016. “Examination of the Hippocampal Contribution to Serotonin 5-HT 2A Receptor-Mediated Facilitation of Object Memory in C57BL / 6J Mice.” Neuropharmacology 109: 332–40.

ZHANG, GONGLIANG, and ROBERT W. STACKMAN JR. 2015. “The Role of Serotonin 5-HT 2A Receptors in Memory and Cognition.” Frontiers in Pharmacology 6(October): 1–17.

Zhu, Bi et al. 2013. “Neurobiology of Learning and Memory True but Not False Memories Are Associated with the HTR2A Gene.” Neurobiology of Learning and Memory 106: 204–9. http://dx.doi.org/10.1016/j.nlm.2013.09.004.




DOI: https://doi.org/10.34119/bjhrv3n2-086

Refbacks

  • There are currently no refbacks.