Preparation and evaluation of the pentavalent antimony-quercetin complex (SbV-QUE) / Preparação e avaliação do complexo antimonial pentavalente-quercetina (SbV-QUE)

Joyelanne Kaline Chagas Souza, Valcilaine Teixeira Barbosa, Joyanne Cristine Chagas Souza, Janaína Barros de Menezes, Luciano Aparecido Meireles Grillo, Camila Braga Dornelas

Abstract


Leishmaniasis is a parasitic disease that has the first choice of treatment medications with antimony as active ingredient. These characteristics justify the search for new compounds with easy administration. In this context, there are quercetin, flavonoid leishmanicidal with chelation power, enabling complexation with metalloids, such as antimony. Thereby, this research aims to prepare and evaluate the complex antimony-quercetin (SbV) in solution and powder form. Precursor materials were quercetin anhydrous (methanolic solution) and potassium hexahydroxoantimonate (V) (aqueous solution), in 1: 1 ratio. After the formation of the complex SbV-QUE SOL (solution), it was dried by rotoevaporation, lyophilization or spray drying. For characterization of SbV-QUE SOL, spectrofluorimetry and UV-Vis spectrophotometry were utilized. In addition, for SbV-QUE powder, X-ray diffraction (XRD), energy dispersive X-Ray analysis (EDX), Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA) and fluorescence microscopy were made. In SbV-QUE SOL, an increase of fluorescence and the bathochromic shift in UV-Vis were observed, demonstrating the formation of the complex. In SbV-QUE powder, a difference of crystallinity between precursors and products was perceived, by XRD analysis. Analyzing DX results, a presence of antimony was observed in the samples. FT-IR indicated the binding site of the complex. Finally, the same thermal profile for the powdered complexes was observed, in addition to the micrographs elucidating the surface morphologies of quercetin and SbV-QUE powder. This confirms the characteristic of post-drying fluorescence. Therefore, the formation of the complex was evidenced, which is essential for further investigation of its use, aiming at leishmaniasis treatment.


Keywords


leishmaniasis; antimonial; quercetin

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References


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DOI: https://doi.org/10.34119/bjhrv2n4-074

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